Hey, I Knew That – Coffee Keeps Your Brain Happy

Hey, I Knew That – Coffee Keeps Your Brain Happy

March 24, 2008 0 Comments

(March 24, 2008) – An interesting article in the current issue of the journal Neuroscience shows that if you want to keep your mouse happy, you have to give him coffee all the time. Read the abstract here: Neuroscience : Chronic but not acute treatment with caffeine attenuates traumatic brain injury in the mouse cortical impact model

I show you this article only half in jest. I am convinced that cognitive science has more to offer than any other field over the next 20 years. I am especially interested in the way brains encode repeated doses of fear and how that plays into conflict. If you want a sneak preview read Wexler’s Brain and Culture.


Caffeine, the most consumed psychoactive drug and non-specific adenosine receptor antagonist, has recently been shown to exert a neuroprotective effect against brain injury in animal models of Parkinson’s disease (PD) and stroke. However, the effects of caffeine on traumatic brain injury (TBI) are not known. In this study, we investigated the effects of acute and chronic caffeine treatment on brain injury in a cortical-impact model of TBI in mice. Following TBI, neurological deficits, cerebral edema, as well as inflammatory cell infiltration were all significantly attenuated in mice pretreated chronically (for 3 weeks) with caffeine in drinking water compared with the mice pretreated with saline. Furthermore, we found that chronic caffeine treatment attenuated glutamate release and inflammatory cytokine production, effects that were correlated with an upregulation of brain A1 receptor mRNA. By contrast, acute treatment with caffeine (i.p. injection, 30 min before TBI) was not effective in protecting against TBI-induced brain injury. These results suggest that chronic (but not acute) caffeine treatment attenuates brain injury, possibly by A1 receptor-mediated suppression of glutamate release and inhibition of excessive inflammatory cytokine production. These results highlight the potential benefit of chronic caffeine intake for preventing TBI and provide a rationale for the epidemiological investigation of the potential association between TBI and human caffeine intake.

John Rutledge


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